Clinical aspects of neurolathyrism in Unnao, India

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Grass pea consumption & present scenario of neurolathyrism in Maharashtra State of India

BACKGROUND & OBJECTIVES Neurolathyrism is a non progressive motor neuron disorder engendered by the prolonged over-consumption of Lathyrus sativus (grass pea) seeds which contain a neurotoxic amino acid, β-N oxalyl- L-α, β-diaminopropionic acid (β-ODAP). It is characterized by spastic paraparesis in the hind limbs. The present study was conducted in 105 households (HHs) of Gondia district in Ma...

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Cassava Cyanide Diseases & Neurolathyrism Network

Fifty year ago, a paper in Biochemistry by Professor S.L.N. Rao described the chemical structure of a new amino acid occurring abundantly in the seeds of Lathyrus sativus and believed to be the cause of the human crippling disease neurolathyrism. Since then this non-protein amino acid β-N-oxalyl-l-α, βdiaminopropionic acid or β-ODAP, has been the focus of numerous studies in a great variety of ...

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Peripheral and central conduction studies in neurolathyrism.

To study the involvement of motor and sensory pathways in neurolathyrism, 19 patients with lathyrism from Unnao, India, where lathyrism is endemic, were studied. The mean age of the patients at the time of the onset of illness was 35.8 (range 18-70) years. The mean duration of illness was 15.6 (range 2-30) years. The clinical picture comprised walking difficulty due to stiffness and mild weakne...

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Emergency Referral Transport for Maternal Complication: Lessons from the Community Based Maternal Death Audits in Unnao District, Uttar Pradesh, India

Background An effective emergency referral transport system is the link between the home of the pregnant woman and a health facility providing basic or comprehensive emergency obstetric care. This study attempts to explore the role of emergency transport associated with maternal deaths in Unnao district, Uttar Pradesh (UP).   Methods A descriptive study was carried out to assess the causes of a...

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ژورنال

عنوان ژورنال: Spinal Cord

سال: 1993

ISSN: 1362-4393,1476-5624

DOI: 10.1038/sc.1993.44